Endocrine Abstracts

Low-grade gliomas are the most common brain tumor in children, accounting for 30–50% of central nervous system tumors in the pediatric age group. They can occur anywhere within the central nervous system (CNS) including the optic pathway (5%). When optic gliomas involve the hypothalamus, patients will often present endocrinopathy. Signs of such involvement can include growth failure and precocious puberty. In this report, we present the case of 8 years three months girls ...

Hypohidrotic ectodermal dysplasia (HED) is a rare genetic disorder characterized by the faulty development of the ectodermal structure, resulting in most notably anhydrosis/hypohydrosis, hypotrichosis and hypodontia. Affected individuals tend to have sparse scalp and body hair (Hypohidrotic), absent teeth (hypodontia) or small and pointed teeth. HED is associated with distinctive facial features including a proeminent forehead, thick lips, and flattened bridge of the nose. The...

IntroductionInsulinoma is the most frequent pancreatic endocrine tumor and is confirmed in case of a hyperinsulinic hypoglycemia with elevated C-peptide and absence of sulfonylureas. Tomodensitometry, MRI, endoscopic ultrasound are the imaging means used to assess localization before surgery as it is not always determined by one mean only, and in a few cases, all means may not determine localization.MethodsTh...

IntroductionSpontaneous hypoglycemia in non-diabetic adults represent a challenge in confirming the organic cause, requiring in that case specific medication or surgery, in a setting of a possible life-threatening disease.MethodsWe conducted a retrospective study of patients admitted in our department for spontaneous hypoglycemia. Functional and factitious etiology were excluded. Clinical and biologic feature...

IntroductionAs hypoglycemia is a common symptom, an organic cause is always the first diagnosis looked for as it can be associated with a specific medical or surgical treatment. Diagnosis of functional etiology isn’t as precise, as the whipple triad can be incomplete. We herein report a serie of confirmed etiology for functional hypoglycemia.MethodsThis is a descriptive retrospective study including 20 c...

Background: Primary hyperparathyroidism is a common endocrine disorder characterized by hypercalcemia, resulting from excessive secretion of parathyroid hormone. Parathyroidectomy, is considered as the definitive treatment for this condition, leading in most cases to remission and resolution of hypercalcemia. However, some patients experience surgical failure. Persistent hyperparathyroidism is defined as persistence of hypercalcemia after parathyroidectomy or recurrence of hyp...

Background: Primary hyperparathyroidism, is defined by hypercalcemia associated with an elevated or inappropriately normal parathyroid hormone(PTH) levels stemming from hyperfunctioning parathyroid glands. It’s a prevalent endocrine disorder. Parathyroidectomy, the surgical excision of affected glands, stands as the definitive treatment, typically resulting in remission and normalization of calcium levels. However, persistent elevation of serum PTH post-parathyroidectomy ...

Introduction: Wilson’s disease is a rare and serious genetic disorder. The accumulation of copper in glands causes several endocrine pathologies. Herein, we report a rare case of hypophysitis with corticotropic deficiency caused by Wilson’s disease.Observation: A 33-years-old female patient was referred to the endocrinology department for hypoglycemia. She had a history of Wilson’s disease diagnosed at the age of nine complicated by cirrho...

Introduction: Isolated hypogonadotropic hypogonadism is a heterogeneous group of genetic abnormalities affecting the hypothalamic pituitary gonadal axis. The main mechanism consists of an impairment of the production or the action of gonadotropin releasing hormone (GnRH). While several mutations have been identified, the majority of cases remain without etiology. The objective of our study was to describe the clinical and biological profiles of these diseases.<p class="abs...

Introduction: Thyroid eye disease (TED) is an autoimmune inflammatory disorder affecting the orbital tissues. It occurs with thyroid dysfunction notably Graves’ disease. TED exhibits different severity patterns and has a lot of risk factors. We, herein, report a rare case of a severe TED developing after COVID-19 infection in a patient initially treated for hyperthyroidism without ocular manifestations.Observation: A 48-year-old female with a histor...